Ausgewählte Publikationen

Gromova KV, Muhia M, Rothammer N, Gee, CE, Thies E, Schaefer I, Kress S, Kilimann MW, Shevchuk O, Oertner TG, Kneussel M (2018) Neurobeachin and the Kinesin KIF21B are critical for Endocytic Recycling of NMDA Receptors and Regulate Social Behavior. Cell Reports 23:2705–2717.

Heisler FF, Pechmann Y, Wieser I, Altmeppen HC, Veenendaal L, Muhia M, Schweizer M, Glatzel M, Krasemann S, Kneussel M (2018) Muskelin coordinates PrPC 1 lysosome versus exosome targeting and impacts prion disease progression. Neuron 99:1155-1169.e9

Schiewek J, Schumacher U, Lange T, Wikman H, Pantel K, Mikhaylova M, Kneussel M, Linder S, Schmalfeldt B, Oliveira-Ferrer L, Windhorst S (2018) Clinical relevance of cytoskeleton associated proteins for ovarian cancer. J Cancer Res Clin Oncol 144:2195-2205.

Vulinovic F, Krajka V, Hausrat TJ, Seibler P, Alvarez-Fischer D, Park J-S, Kumar KR, Sue CM, Lohmann K, Kneussel M, Klein C, Rakovic A (2018) Motor protein binding and mitochondrial transport are altered by pathogenic TUBB4A variants. Hum Mutat 39:1901-1915.

Maric HM, Hausrat TJ, Neubert F, Dalby NO, Doose S, Sauer M, Kneussel M, Stromgaard K (2017) Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission. Nat Chem Biol 13:153-160.

Vogl C, Butola T, Haag N, Hausrat T, Leitner M, Moutschen M, Lefebvre P, Speckmann C, Garrett L, Becker L, Fuchs H, Hrabe de Angelis M, Nietzsche S, Oliver D, Kessels M, Kneussel M, Kilimann M, Strenzke N (2017) The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing. EMBO Rep 18:2015-2029.

Brill MS*, Kleele T*, Ruschkies L*, Wang M, Marahori NA, Reuter MS, Hausrat TJ, Weigand E, Fisher M, Ahles A, Engelhardt S, Bishop DL, Kneussel M, Misgeld T (2016) Branch-specific microtubule destabilization mediates axon branch loss during neuromuscular synapse elimination. Neuron 92:845-856. *Co-first authors

Cheng J*, Sahani S*, Hausrat TJ*, Yang JW, Ji H, Schmarowski N, Endle H, Liu X, Li Y, Bottche R, Radyushkin K, Maric HM, Hoerder-Suabedissen A, Molnar Z, Prouvot PH, Trimbuch T, Ninnemann O, Huai J, Fan W, Visentin B, Sabbadini R, Stromgaard K, Stroh A, Luhmann HJ, Kneussel M, Nitsch R, Vogt J (2016) Precise somatotopic thalamocortical axon guidance depends on LPA-mediated PRG-2/Radixin signaling. Neuron 92:126-142. *Co-first authors

Ghiretti AE, Thies E, Tokito MK, Lin T, Ostap EM, Kneussel M, Holzbaur EL (2016) Activity-dependent regulation of distinct transport and cytoskeletal remodeling functions of the dendritic kinesin KIF21B. Neuron 92:857-872.

Kneussel M, Hausrat TJ (2016) Postsynaptic neurotransmitter receptor reserve pools for synaptic potentiation. Trends Neurosci 39:170-182.

Muhia M, Thies E, Labonte D, Ghiretti AE, Gromova KV, Xompero F, Lappe-Siefke C, Hermans-Borgmeyer I, Kuhl D, Schweizer M, Ohana O, Schwarz JR, Holzbaur EL, Kneussel M (2016) The kinesin KIF21B regulates microtubule dynamics and is essential for neuronal morphology, synapse function, and learning and memory. Cell Rep 15:968-977.

Schwarz JR (2016) Ca(2+) channels in the node of Ranvier: new insights into modulation of nodal excitability. J Physiol 594:3-4.

Shimobayashi E, Wagner W, Kapfhammer JP (2016) Carbonic anhydrase 8 expression in Purkinje cells is controlled by PKCγ activity and regulates Purkinje cell dendritic growth. Mol Neurobiol 53:5149-5160.

Delto CF, Heisler FF, Kuper J, Sander B, Kneussel M, Schindelin H (2015) The LisH motif of muskelin Is crucial for oligomerization and governs intracellular localization. Structure 23:364-373.

Hausrat TJ, Muhia M, Gerrow K, Thomas P, Hirdes W, Tsukita S, Heisler FF, Herich L, Dubroqua S, Breiden P, Feldon J, Schwarz JR, Yee BK, Smart TG, Triller A, Kneussel M (2015) Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory. Nat Commun 6:872.

Maric HM, Kasaragod VB, Haugaard-Kedstrom L, Hausrat TJ, Kneussel M, Schindelin H, Stromgaard K (2015) Design and synthesis of high-affinity dimeric inhibitors targeting the interactions between gephyrin and inhibitory neurotransmitter receptors. Angew Chem Int Edit 54:490-494.

Rathgeber L, Gromova KV, Schaefer I, Breiden P, Lohr C, Kneussel M (2015) GSK3 and KIF5 regulate activity-dependent sorting of gephyrin between axons and dendrites. Eur J Cell Biol 94:173-178.

Rosso JP, Schwarz JR, Diaz-Bustamante M, Ceard B, Gutierrez JM, Kneussel M, Pongs O, Bosmans F, Bougis PE (2015) MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity. Proc Natl Acad Sci U S A 112:E891-900.

Kneussel M, Triller A, Choquet D. SnapShot: receptor dynamics at plastic synapses. Cell (2014), 157, 1738-1739.

Petrini EM, Ravasenga T, Hausrat TJ, Iurilli G, Olcese U, Racine V, Sibarita JB, Jacob TC, Moss SJ, Benfenati F, Medini P, Kneussel M, Barberis A. Synaptic recruitment of gephyrin regulates surface GABA-A receptor dynamics for the expression of inhibitory LTP. Nature Communications (2014) 5: 3921.

Heisler FF*, Lee HK*, Gromova KV, Pechmann Y, Schurek B, Ruschkies L, Schroeder M, Schweizer M, Kneussel M. GRIP1 interlinks N-Cadherin and AMPA receptors at vesicles to promote combined cargo transport into dendrites. Proc. Natl. Acad. Sci. USA (2014), 111, 5030-5035.

Kneussel M, Wagner W. Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics. Nature Reviews Neuroscience (2013), 14, 233-247.

Schattling B, Steinbach K, Thies E, Kruse M, Menigoz A, Ufer F, Flockerzi V, Brück W, Pongs O, Vennekens R, Kneussel M, Freichel M, Merkler D, Friese MA. TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Nature Medicine (2012), 18, 1805-1811.

Heisler FF, Loebrich S, Pechmann Y, Maier N, Zivkovic AR, Tokito M, Hausrat TJ, Schweizer M, Bähring R, Holzbaur EL, Schmitz D, Kneussel M. Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons. Neuron. 2011 Apr 14;70(1):66-81. doi: 10.1016/j.neuron.2011.03.008. PubMed PMID: 21482357; PubMed Central PMCID: PMC3101366.

Schapitz IU, Behrend B, Pechmann Y, Lappe-Siefke C, Kneussel SJ, Wallace KE, Stempel AV, Buck F, Grant SG, Schweizer M, Schmitz D, Schwarz JR, Holzbaur EL, Kneussel M. Neuroligin 1 is dynamically exchanged at postsynaptic sites. Journal of Neuroscience 2010 Sep 22;30(38):12733-44. doi:10.1523/JNEUROSCI.0896-10.2010. PubMed PMID: 20861378; PubMed Central PMCID: PMC3108891.

Janke C, Kneussel M. Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton. Trends in Neurosciences 2010 Aug;33(8):362-72. doi: 10.1016/j.tins.2010.05.001. Epub 2010 Jun 11. Review. PubMed PMID: 20541813.

Lappe-Siefke C, Loebrich S, Hevers W, Waidmann OB, Schweizer M, Fehr S, Fritschy JM, Dikic I, Eilers J, Wilson SM, Kneussel M. The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice. PLoS Genetics 2009 Sep;5(9):e1000631. doi: 10.1371/journal.pgen.1000631. Epub 2009 Sep 4. PubMed PMID: 19759851; PubMed Central PMCID: PMC2744266.

Maas C, Belgardt D, Lee HK, Heisler FF, Lappe-Siefke C, Magiera MM, van Dijk J, Hausrat TJ, Janke C, Kneussel M. Synaptic activation modifies microtubules underlying transport of postsynaptic cargo. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8731-6. doi: 10.1073/pnas.0812391106. Epub 2009 May 13. PubMed PMID: 19439658; PubMed Central PMCID: PMC2681317.

Loebrich S, Bähring R, Katsuno T, Tsukita S, Kneussel M. Activated radixin is essential for GABAA receptor alpha5 subunit anchoring at the actin cytoskeleton. EMBO Journal 2006 Mar 8;25(5):987-99. Epub 2006 Feb 9. PubMed PMID: 16467845; PubMed Central PMCID: PMC1409722.

Kneussel M. Postsynaptic scaffold proteins at non-synaptic sites. The role of postsynaptic scaffold proteins in motor-protein-receptor complexes. EMBO Reports
2005 Jan;6(1):22-7. Review. PubMed PMID: 15643447; PubMed Central PMCID:

Fuhrmann JC, Kins S, Rostaing P, El Far O, Kirsch J, Sheng M, Triller A, Betz
H, Kneussel M. Gephyrin interacts with Dynein light chains 1 and 2, components of
motor protein complexes. Journal of Neuroscience 2002 Jul 1;22(13):5393-402. PubMed PMID: 12097491.

Kneussel M, Brandstätter JH, Gasnier B, Feng G, Sanes JR, Betz H. Gephyrin-independent clustering of postsynaptic GABA(A) receptor subtypes. Molecular and Cellular Neuroscience 2001 Jun;17(6):973-82. PubMed PMID: 11414787.

Kneussel M, Betz H. Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: the membrane activation model. Trends in Neurosciences 2000 Sep;23(9):429-35. Review. PubMed PMID: 10941193.

Kneussel M, Haverkamp S, Fuhrmann JC, Wang H, Wässle H, Olsen RW, Betz H. The
gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8594-9. PubMed PMID: 10900017; PubMed Central PMCID: PMC26993.

Kneussel M, Brandstätter JH, Laube B, Stahl S, Müller U, Betz H. Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient mice. Journal of Neuroscience 1999 Nov 1;19(21): 9289-97. PubMed PMID: 10531433.

Publikationen Matthias Kneussel